Ekstrak Daun Keji Beling (Strobilanthes crispus L.) Uuntuk Penurunan Kadar Kolesterol Pada Tikus Putih Jantan (Ratus norvegicus) Galur Wistar
Keji Beling (Strobilanthes crispus L.) Leaf Extract for Reducing Cholesterol Levels in Male White Rats (Ratus norvegicus) Wistar strain
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(1) * Fadila Abd Rachman
Universitas Muhammadiyah Sidoarjo
Indonesia
(2) Syahrul Ardiansyah
Universitas Muhammadiyah Sidoarjo
Indonesia
(*) Corresponding Author
Abstract
Indonesian citizens have a various lifestyle impacts on the increasing of blood-cholesterol level. One of the potential herbal medicine is keji beling leaves (Strobilanthes crispus L.) because of these leaves contains flavonoid and sterol. This study aims to analyze the efficacy of Strobilanthes crispus L. leaves extract to decrease the blood-cholesterol level. This research is experimental laboratory with pretest – post test only control group design. The total of 24 Wistar rats were divided into six groups, as follow: negative control, positive control, treated with 25%, 50%, 75% and 100% Strobilanthes crispus L. extract. The therapy was administrated for 14 days. Cholesterol test using POCT method. The data were analyzed using Repeated Measured Anova. The results showed that Strobilanthes crispus L. leaves extracts potentially decreased on blood-cholesterol level in Wistar rats after 14 days of treatment. This study reflected that the Strobilanthes crispus L. leaves extract can be used as the alternative therapy on the blood-cholesterol level. The greatest decrease in P4 (100% concentration).
References
Almatsier, S. (2006). Prinsip Dasar Ilmu Gizi. Jakarta: Gramedia Pustaka Utama.
Astawan, M. (2004). Bersahabat dengan Kolesterol. Solo: Tiga Serangkai.
Dalimartha S. (2006). Atlas Tumbuhan Obat Indonesia. Jakarta: Puspa Swara.
Dewi, R.Y., Santoso, L.M., Tibrani, M.M. (2012). Uji Efektifitas Air Perasan Buah Nanas (Ananascomosus (L.) Merr.) Terhadap Kadar Kolesterol Total dan Trigliserida Darah Mencit (Musmusculus L.) Serta Sumbangannya Pada Pembelajaran Biologi Di Sekolah Menengah Atas. Jurnal Pendidikan Biologi FKIP Universitas Sriwijaya. Retrieved from https://s1farmasi.blogspot.com/2014/03/uji-efektivitas-air-perasan-buah-nanas.html
Djojosoebagio, S. & Piliang, W. G. (1996). Fisiologi Nutrisi. Edisi ke-2. Jakarta: UI Press.
Fadzelly, Mohd. (2006). Effects of Strobilanthes crispus Tea Aqueous Extracts on Glucose and Lipid Profile in Normal and Streptozotocin-Induced Hyperglycemic Rats. Plant Foods For Human Nutrition Jurnal, 61(1), 6-11. Doi: 10.1007/s11130-006-0002-z DOI: https://doi.org/10.1007/s11130-006-0002-z
Juhcini. (2002). Pemanfaatan Herbal Seledri (Apium graveolens L.) Untuk Menurunkan Kolesterol dan Lipid dalam Darah Tikus Putih yang Diberi Diit Tinggi Kolesterol dan Lemak. Makara, Sains, 6(2), 65-69. Retrieved from https://ejournal.ui.ac.id/index.php/science/article/download/127/123
Wijaya, N. E. A., Kandou, G. D., & Lampus, B. S. (2013). Gambaran Kebiasaan Makan Masyarakat di Perumahan Alandrew Permai Kelurahan Malalayang I Lingkungan XI Kota Manado. Jurnal Kedokteran Komunitas dan Tropik. 1(3), 88-93. Retrieved https://ejournal.unsrat.ac.id/index.php/JKKT/article/view/3321/2873
Limantara, L. (2009). Daya Penyembuhan Klorofil. Malang: Ma Chung Presss.
Murray, R. K., Granner, D. K., & Rodwell, V. W. (2009). Biokomia Herper. Edisi 27. Jakarta: ECG.
Prasetyo. (2002). Air Kelapa Muda sebagai Minuman Isotonik Alami. Jakarta: UI.
Rahmat, A., & Fakurazi, S. (2006). Antiproliferative Properties and Antioxidant Activity of Various Types of Strobilanthes Crispus Tea. International Jounal of Cancer Research, 2 (2), 152-158. Doi: 10.3923/ijcr.2006.152.158 DOI: https://doi.org/10.3923/ijcr.2006.152.158
Saifudin, A. (2014). Senyawa Alam Metabolit Sekunder Teori, Konsep, dan Teknik Permunian. Edisi Pertama. Yogyakarta: Deepublish.
Sitepoe, M. (1992). Kolesterol Fobia Keterkaitannya dengan Penyakit Jantung. Jakarta: Gramedia Pustaka Utama.
