Pengaruh Infusa Rimpang Temu Putih (Curcuma zedoaria (Berg.) Roscoe) Terhadap Jumlah Leukosit Dan Differential Counting (Diffcount) Pada Kesembuhan Luka Laparatomi Pasca Bedah
Effect of Infusion of Temu Putih Rhizome (Curcuma zedoaria (Berg.) Roscoe) on Leukocyte Count and Differential Counting (Diffcount) on Postoperative Laparotomy Wound Healing
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(1) * Ratna Wulandari
Universitas Muhammadiyah Sidoarjo
Indonesia
(2) Puspitasari Puspitasari
Universitas Muhammadiyah Sidoarjo
Indonesia
(*) Corresponding Author
Abstract
Laparatomy is surgery performed to open the abdominal area which causes an increase in plasma adrenaline and inflammatory. Leukocytes will increase if the adrenal glands are stimulated as a physiological response such as stress and when active against microorganisms. Leukocytosis can trigger an increase in the number of neutrophil and lymphocyte cells in the blood circulation and cause an increase in leukocytes and diffcount. Curcuma zedoaria contain curcumin compounds as antioxidant effectiveness to prevent fisiologis stress, flavonoid and essential oils as an anti-inflammatory which can increase the total of leukocyte. The objective of this research is to determine the effect of several Curcuma zedoaria infusion on the total of leukocytes and diffcount on post operative laparatomy wound healing. A total of 24 Rattus norvegicus were used in this research. Group I (without infusion); group II (10% infusion); group III (15% infusion); group IV (20% infusion). Rattus norvegicus were sreened laparatomy and their blood was taken for leukocyte and differential counting. There is an effect of Curcuma zedoaria infusion on the number of leukocytes and diffcount. The best concentration 15% of leukocyte, and diffcount such as concentration 20% granulocyte, concentration 15% lymphocytes and concentration 10% monocyte in postoperative laparatomy wound healing.
References
Agrawal, A. D. (2011). Pharmacological Activities of Flavonoids: A Review. International Journal of Pharmaceutical Sciences and Nanotechnology, 4(2), 1394-1398. Retrieved from http://www.ijpsnonline.com/Issues/1394_full.pdf DOI: https://doi.org/10.37285/ijpsn.2011.4.2.3
Bellik, Y., Boukraâ, L., Alzahrani, H. A., Bakhotmah, B. A., Abdellah, F., Hammoudi, S. M, & Iguer-Ouada, M. (2012). Molecular Mechanism Underlying Anti-Innfammatory and Anti-Allergic Activities of Phytochemicals: An Update. Molecules, 18(1), 322-353. Doi.org/10.3390/molecules 18010322 DOI: https://doi.org/10.3390/molecules18010322
Departemen kesehatan RI. (2009). Riset Kesehatan Dasar. Jakarta: Departemen Kesehatan.
Desto, P. (2012). Efek Pemberian Ekstrak Daun Sirih (Piper Betle L.) Pada Jumlah Leukosit Darah Tepi Model Hewan Coba Tikus yang Dipapar Candida albicans Secara Intrakutan. Skripsi. Universitas Jember. Jember.
Ditya, W., Zahari, A., & Afriwardi. (2016). Hubungan Mobilisasi Dini dengan Proses Penyembuhan Luka pada Pasien Pasca Laparatomi di Bangsal Bedah Pria dan Wanita RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 5(3), 724-729. DOI: https://doi.org/10.25077/jka.v5.i3.p%25p.2016 DOI: https://doi.org/10.25077/jka.v5i3.608
Gomes, A., Fernandes, E., Lima, J. L., Mira, L., & Corvo, M. L. (2008). Molecular Mechanisms of Anti-Inflammatory Activity Mediated by Flavonoids. Current Medicinal Chemistry, 15(16), 1586-1605. DOI: 10.2174/092986708784911579 DOI: https://doi.org/10.2174/092986708784911579
Gunawijaya, F. A., Hartono, A., & Djuantoro, D. (2013). Sinopsis Organ System Hematologi Dan Onkologi. Tanggerang Selatan: Kharisma Publishing.
Hafiz, I. (2016). Uji Aktivitas Antioksidan Dan Antiinflamasi Ekstrak Etanol Daun Pagoda (Clerodendrum paniculatum L.) Terhadap Tikus Putih Jantan (Rattus novergicus). Tesis. Program Studi Magister Farmasi Fakultas Farmasi Universitas Sumatra Utara. Medan.
Kandy, A.P. (2016). Uji Aktifitas Anti Inflamasi Kombinasi Ekstrak Etanol Jahe Merah (Zingiber officinale var. rubrum) dan Daun Sidaguri (Sida rumbifolia L.) terhadap Jumlah Neutrofil Tikus yang Dinduksi Karagenin. Skripsi. Fakultas Farmasi Universitas Negeri Jember. Jember.
Maulida, R. (2008). Pengaruh Pemberian Ekstrak Etanol Rimpang Temu Putih (Curcuma zedoaria (Berg.) Roscoe) Terhadap Jumlah dan Diferensiasi Leukosit pada Kelinci yang Diinduksi Tumor dan Diterapi Dengan Operasi. Skripsi. Fakultas Kedokteran Hewan Institut Pertanian Bogor. Bogor.
Permatasari, E. D. (2010). Gambaran Jumlah Total Dan Diferensiasi Leukosit Sebelum Dan Sesudah Mastektomi Dan Ovariohiterektomi Pada Kelinci Yang Diinduksi Tumor Dan Diobati Dengan Ekstrak Rimpang Temu Putih (Curcuma zedoaria (Berg.) Roscoe). Skripsi. Fakultas Kedokteran Hewan Institut Pertanian Bogor. Bogor.
Saputri, D. N. E. (2010). Jumlah Total dan Diferensial Leukosit Mencit (Mus Musculus) Pada Evaluasi In Vivo Antikanker Ekstrak Spons Laut Aaptos Suberitoides. Skripsi. Program Studi Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam. Institut Teknologi Sepuluh Nopember. Surabaya.
Sartika, D., Suarnianti, & Ismail, H. (2013). Pengaruh Komunikasi Tarapeutik Terhadap Tingkat Kecemasan Pasien Pre Operasi Di ruang Perawatan Bedah RSUD Kota Makassar. Jurnal Universitas Hasanuddin Makassar, 3(3), 18-22. Retrieved from http://ucs.sulsellib.net//index.php?p=show_detail&id=101246
Sujono, T. A., Patimah, R., & Yuliani, R. (2012). Efek Antiinflamasi Infusa Rimpang Temu Putih (Curcuma zedoaria (Berg) Roscoe) Pada Tikus Yang Diinduksi Karagenin. Biomedika, 4(2), 10-17. DOI: https://doi.org/10.23917/biomedika.v4i2.253 DOI: https://doi.org/10.23917/biomedika.v4i2.253
Yuliarti, N. (2009). A to Z Food Supplement Edisi 1. Yogyakarta: ANDI.
