The Relationship Between Widal Titer with Platelet and Leukocyte Counts In Typhioid Fever Patients
Hubungan Titer Widal Dengan Jumlah Trombosit dan Leukosit Pada Pasien Demam Tifoid
DOI:
https://doi.org/10.21070/medicra.v9i1.1827Keywords:
Hematology, Leukocyte, Platelet, Typhoid Fever, Widal TiterAbstract
Typhoid fever is a systemic infectious disease caused by Salmonella typhi and remains a health problem in developing countries, including Indonesia. The Widal test is still widely used as a supporting diagnostic examination for typhoid fever because it is simple and rapid. Typhoid infection may also cause changes in hematological parameters such as leukocyte and platelet counts. This study aimed to determine the relationship between Widal titers and leukocyte and platelet counts in typhoid fever patients. This study used a quantitative design with a cross-sectional approach. A total of 21 typhoid fever patients were selected using purposive sampling technique. Leukocyte and platelet examinations were performed using the Mindray BC 5300 Hematology Analyzer. Data analysis was conducted using the Shapiro-Wilk normality test followed by Spearman correlation test. The results showed that the correlation between Widal titer and leukocyte count obtained p=0.987 and r=0.004, while the correlation between Widal titer and platelet count obtained p=0.935 and r=0.019. These findings indicate that there was no significant relationship between Widal titer and leukocyte or platelet counts in typhoid fever patients. However, there was a significant relationship between leukocyte and platelet counts with p=0.000 and correlation coefficient r=0.753. In conclusion, Widal titer had no significant relationship with leukocyte and platelet counts in typhoid fever patients, while leukocyte and platelet counts showed a strong positive correlation.
References
Carestia A, Godin LC, Jenne CN. (2023). Step up to the platelet: Role of platelets in inflammation and infection. Thrombosis Research, 231:182–194. DOI: 10.1016/j.thromres.2022.10.001.
Chaudhary, V., Bharath, B.R., Ramesh, K.K.(2025). Haematological profile in typhoid fever: an update from a tertiary rural hospital. International Journal of Community Medicine and Public Health. 12(11):5177–5180. DOI: 10.18203/2394-6040.ijcmph20253702
Dafidela, W., Haiga, Y., Putriyuni, A., Anggraini, D.(2020). Gambaran Karakteristik Pasien Konfirmasi Covid-19 Di RSUD Dr. Rasidin Padang Tahun 2020. Scientific Journal, 2(1), 11-15. DOI: https://doi.org/10.56260/sciena.v2i1.84
Daifa, K.I., Anggraeni, R., Putri, W.R. (2025). Gambaran Hasil Pemeriksaan Demam Tifoid Metode Widal Dan Igm Anti Salmonella Typhidi Rs Pku Muhammadiyah Gamping. Jurnal Kesehatan Masyarakat, 9(2), 4822–4829.DOI: https://doi.org/10.31004/prepotif.v9i2.48253
Devita N, Riski MS, Marufi R. (2024) Changes in Hematological Parameters of Typhoid Fever Patients at PKU Bantul Hospital, Yogyakarta. Jurnal Kedokteran dan Kesehatan, 12(2), 164-171. DOI: 10.22437/jmj.v12i2.31587
Kamath, A., Poojari, S., & Varsha, K. (2025). Assessing the robustness of normality tests under varying skewness and kurtosis: a practical checklist for public health researchers. BMC Medical Research Methodology, 25, 206. DOI: 10.1186/s12874-025-02641-y.
Loviana, N., Savitri, L., Krissanjaya, R., Kasimo, E.R.(2023). The Correlation Between Widal Diagnostic Test, Total Leukocyte Count, and Platelet Count in Suspected Typhoid Fever Patients at RS Aura Syifa Kediri. Biology, Medicine, & Natural Product Chemistry, 12(2):555–558. DOI: 10.14421/biomedich
Nazilah, A. A., & Suryanto, S.(2013). Hubungan Derajat Kepositifan TUBEX TF dengan Angka Leukosit pada Pasien Demam Tifoid. Mutiara Medika. Jurnal Kedokteran dan Kesehatan, 13(3), 173–180. https://doi.org/10.18196/mmjkk.v13i3.2482
Ndako, J. A., Dojumo, V. T., Akinwumi, J. A., Fajobi, V. O., Owolabi, A. O., & Olatinsu, O. (2020). Changes in some haematological parameters in typhoid fever patients attending Landmark University Medical Center, Omuaran-Nigeria. Heliyon, 6(5), e04002. https://doi.org/10.1016/j.heliyon.2020.e04002.
Nurjanah, M.H., Wijaya, A.F., Fuzianingsih, E.N., Rahmawati, A.S.C., Martha, R.D. (2025). Hubungan Pengetahuan dan Kepatuhan Cuci Tangan terhadap Kejadian Demam Tifoid di Kabupaten Tulungagung. JURNAL BIOSHELL: Jurnal Pendidikan Biologi, Biologi, dan Pendidikan IPA, 14(2), 211–219. DOI: https://doi.org/10.56013/bio.v14i2.4572
Nurmansyah, D., Nisa, S., Puspawati., Fayumi, S., Mudzakkir, M., Sasmitja, M.H. (2025). Profil Jumlah Leukosit Berdasarkan Nilai Titer Widal pada Kasus Demam Tifoid Anak. Jurnal Sains Natural, 3(2), 108-111. DOI: https://doi.org/10.35746/jsn.v3i2.845
Olopoenia LA, King AL.(2020).Widal Agglutination Test–100 Years Later: Still Plagued by Controversy. Postgraduate Medical Journal. 76(892):80–84. DOI: http//doi.org/10.1136/ pmj.76.892.80
Putri, S.P., Anggraeni, R., Novalina, D.(2025). Hubungan Trombositopenia Dengan Infeksi Salmonella typhi Pada Pasien Demam Tifoid Di Rs Pku Muhammadiyah Yogyakarta. Jurnal Analis Laboratorium Medik, 10(2), 137-147. DOI: https://doi.org/10.56359/igj.v4i3.624
Sugiyono. Metode Penelitian Kuantitatif, Kualitatif, dan R&D.(2020). Bandung: Alfabeta
Triana, A., Ratih, W.U., Hadi, W.S.(2025). Hubungan Antara Jumlah Trombosit Leukosit Serta Limfosit Dengan Titer Widal Pada Pasien Demam Tifoid. Jurnal Kesehatan Tambusai, 6(4), 15152-15160 DOI: https://doi.org/10.31004/jkt.v6i4.52707
Tyagi, S., Sharma, S.R.(2025). Comparative Study of the Performance of Widal Test and Typhi Dot Immunoassay for the Diagnosis of Typhoid Fever. Journal of Contemporary Clinical Practice, 11(7):457–461.DOI: 10.61336/jccp/25-07-60
Wibowo, A., Setiawan, R., Lestari, P.(2021). Respons Imun dan Perubahan Hematologi pada Demam Tifoid. Jurnal Kedokteran Diponegoro, 10(3):130–138. DOI:10.31305/rrijm.2021.v06.i05.013
Widary, B.L., Danuyanti, I.G.A.N., Zaetun, S. (2021). Hubungan Titer Widal dengan Jumlah dan Indeks Trombosit Penderita Demam Tifoid di Puskesmas Lombok Barat. Jurnal Kesehatan Andalas, 10(3). 138-142.DOI: http://doi.org/10.25077/jka.v10i3.1792
Yuniarti, R., Hartiani., Harizahayu. (2025). Pengaruh Distribusi Data Terhadap Hasil Uji Korelasi Studi Pada Uji Pearson Product Moment, Rank Spearman, dan Rank Kendall Tau. Unisda Journal of Mathematics and Computer Science, 11(1), 9-16. DOI: 10.52166/ujmc.v11i1.9439.
Zareifar, S., Farahmand Far, M. R., Golfeshan, F., & Cohan, N. (2014). Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. Journal of Clinical Laboratory Analysis, 28(3), 245–248. https://doi.org/10.1002/jcla.21673
Downloads
Additional Files
Published
How to Cite
License
Copyright (c) 2026 Mutia Hariani Nurjanah
This work is licensed under a Creative Commons Attribution 4.0 International License.
