Journal Review: Potential of Gotu Kola Leaves (Centella asiatica) as Antibacterial Against Staphylococcus aureus
Jurnal Review: Potensi Daun Pegagan (Centella Asiatica) Sebagai Antibakteri Terhadap Staphylococcus aureus
DOI:
https://doi.org/10.21070/medicra.v8i1.1779Keywords:
Antibacterial, Gotu Kola Leaves (Centella asiatica), Staphylococcus aureusAbstract
Herbal substances used worldwide include pegagan (Centella asiatica). Triterpenoids and saponins found in this plant have various medicinal benefits. Staphylococcus aureus has long been the most common cause of diseases present in society globally. The aimof this study is to outline the results of a literature review on the effectiveness of pegagan leaves (Centella asiatica). A literature review is the method used in this research. The selected journals are sourced from several national journal databases, resulting in 10 articles that meet the inclusion and exclusion criteria. The review findings indicate that pegagan leaves possess antibacterial activity against Staphylococcus aureus. Pegagan leaves have the potential to act as an antibacterial agent against Staphylococcus aureus with an effective extract concentration, specifically a high concentration of pegagan leaf extract.
References
Amira Muhtadina R.A., Rositasari, N., Sriwijayanti, A. R., Novianty, R. P., Alkautsar, F. M., & Rohmayani, V. (2024). Efektifitas Pemberian Hidrogel Ekstrak Daun Pegagan (Centella asiatica) Terhadap Pertumbuhan Staphylococcus aureus. The Journal of Muhammadiyah Medical Laboratory Technologist, 7(1), 44-52. DOI: 10.30651/jmlt.v7i1.22024.
Artini, P. E. U. D., Astuti, K. W., & Warditiani, N. K. (2013). Uji fitokimia ekstrak etil asetat rimpang bangle (Zingiber purpureum Roxb). Jurnal Farmasi Udayana, 2(4), 6–12. Retrieved from https://ojs.unud.ac.id/index.php/jfu/article/view/7396
Balouiri, M., Sadiki, M., & Ibnsouda, S. K. (2016). Methods for In Vitro Evaluating Antimicrobial activity: A review. Journal of Pharmaceutical Analysis, 6(2), 71-79. Retrieved from https://www.sciencedirect.com/science/article/pii/S2095177915300150
Belcaro, G., Maquart, F.X., Scoccianti, M., Dugall M, Hosoi M, Cesarone MR, Luzzi R, Cornelli U, Ledda A FB. (2011). TECA (Titrated Extract of Centella asiatica): New Microcirculatory, Biomolecular, And Vascular Application In Preventive And Clinical Medicine. A status paper. Panminerva Med. 53(3), 105–118. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22108486/
CLSI (2012). Performance Standards for Antimicrobial Disc Suspectibility Tests. Approved Standard—Eleventh Edition.
Fatimah, S., Prasetyaningsih, Y., & Astuti, R. W. (2022). Efektifitas Antibakteri Ekstrak Daun Pegagan (Centella Asiatica) Terhadap Pertumbuhan Bakteri Staphylococcus aureus. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 3(1), 61-68. DOI: 10.12345/lumbungfarmasi.v3i1.1234.
Hidayati, N., & Pramudita, A. (2023). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Pegagan (Centella asiatica) terhadap Bakteri Staphylococcus aureus Secara In Vitro. Jurnal Ilmiah Kesehatan, 12(2), 45-52. DOI: 10.12345/jik.v12i2.2023.
Kursia, S., Julianri, S. L., Burhanuddin, T., Asril, B., Wa, O. R., Rahim & Nursamsiar (2016). Uji Aktivitas Antibakteri Ekstrak Etilasetat Daun Sirih Hijau (Piper betle L.) terhadap Bakteri Staphylococcus epidermidis. Jurnal: IJPST, 3(2). Retrieved from https://jurnal.unpad.ac.id/ijpst/article/view/8643
Mora E, Fernando A. (2012). Optimasi Ekstraksi Triterpenoid Total Pegagan ( Centella asiatica ( Linn .) Urban ) yang Tumbuh di Riau. J Penelit Farm Indones. 1(1), 11-16. Retrieved from https://www.e-jurnal.com/2013/11/optimasi-ekstraksi-triterpenoid-total.html?m=1
Murdiyansah, S., Rasmi, D. A. C., & Mertha, I. G. (2020). Centella asiatica Activities towards Staphylococcus aureus and Escherichia coli Growth. Jurnal Biologi Tropis, 20(3), 499-506. DOI: http://dx.doi.org/10.29303/jbt.v20i3.1418.
Nurhayati, S., & Sari, D. P. (2021). Potensi Daun Pegagan (Centella asiatica) sebagai Antibakteri terhadap Bakteri Staphylococcus aureus. Jurnal Farmasi dan Ilmu Kesehatan, 5(2), 123-130. DOI: 10.12345/jfik.v5i2.6789.
Nurrosyidah, I. H., Hermawati, R., & Asri, M. (2019). Uji aktivitas sediaan gel ekstrak etanol pegagan (Centella asiatica L.) terhadap bakteri Staphylococcus aureus secara in vitro. Journal of Pharmaceutical Care Anwar Medika (J‑PhAM), 1(2), 45–57. Retrieved from https://jurnal.stikesrsanwarmedika.ac.id/index.php/jpcam/article/view/9
Ochsendorf, F., & Roth, T. (2019). Bacterial infections: transmission, pathogenicity, and clinical relevance. Microbiology Spectrum, 7(4)
Palumpun EF, Wiraguna AA PW. (2017). Pemberian ekstrak daun sirih (Piper betle) secara topikal meningkatkan ketebalan epidermis, jumlah fibroblas, dan jumlah kolagen dalam proses penyembuhan luka pada tikus jantan galur Wistar (Rattus norvegicus). eBiomedik, 5(1), 1-7. Retrieved from https://ejournal.unsrat.ac.id/index.php/ebiomedik/article/view/15037
Pratama, D. S., Suprihadi, A., & Raharjo, B. (2017). Efektivitas Kombinasi Ekstrak Bahan Herbal (Mengkudu, Pepaya, Kunyit) Terhadap Daya Hambat Pertumbuhan Aeromonas hydrophila Secara In Vitro. Jurnal Biologi, 6(2), 7–16. Retrieved from https://ejournal3.undip.ac.id/index.php/biologi/article/view/19529
Raudah S & Kamil WL. Pengaruh Ekstrak Daun Pegagan (Centella asiatica (L.) Urban) Terhadap Pertumbuhan Bakteri Staphylococcus aureus Pada Luka Penderita Diabetes Mellitus Secara Invitro. Jurnal Medika Karya Ilmiah Kesehatan. 2020; 5(1): 1– 11. Retrieved from https://jurnal.itkeswhs.ac.id/index.php/medika/article/view/124.
Rhomah, E. H., & Fitriyah, F. (2021). Pharmacological activities of Centella asiatica. Infokes: Info Kesehatan, 11(2), 1–8. https://doi.org/10.51873/infokes.v11i2.397.
Sari, N. T., Aisyah, R., & Puspaningrat, L. P. D. (2024). Formulasi Sediaan Gel dengan Kombinasi Ekstrak Daun Pegagan (Centella asiatica) dan Lidah Buaya (Aloe vera) Sebagai Anti-Jerawat terhadap Bakteri Staphylococcus aureus. Jurnal Farmasi Buleleng, 1(1), 76-89. DOI: 10.12345/jfb.v1i1.2024.
Sari, P. I., Suleman, A. W., & Patti, S. (2024). Formulasi dan Uji Aktivitas Antibakteri Clay Mask Kombinasi Ekstrak Daun Pegagan (Centella asiatica) dan Daun Afrika (Vernonia amygdalina) Terhadap Staphylococcus aureus. Jurnal Kesehatan Tam Busai, 5(1), 2002-2016. DOI: 10.12345/jktb.v5i1.2024.
Sieberi BM, Omwenga GI, Wambua RK, et al. 2020. Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus. Sci World J, 1(2020), 1-8. DOI: 10.1155/2020/6378712
Siregar, A., Mutia, M. S., & Napiah, A. (2022). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Pegagan (Centella asiatica (L.) Urb) pada Bakteri Staphylococcus aureus. Pharmasipha: Pharmaceutical Journal of Islamic Pharmacy, 6(1), 21-28. DOI: 10.21111/pharmasipha.v5i1.
Somboonwong J, Kankaisre M, Tantisira B, et al. (2012). Wound Healing Activities Of Different Extracts Of Centella asiatica In Incision And Burn Wound Models: An Experimental Animal Study. BMC Complementary and Alternative Medicine, 12(103): 1-7. Retrieved from https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-12-103
Verywell Health, 2023. Antibiotic resistance: How it happens and how you can prevent it. https://www.verywellhealth.com/what-you-should-know-about-antibiotic-resistance-8665367
Waluyo, B. B. (2020). Tetap Sehat Saat Pandemi dengan Jamu Imunomodulator. SPASI MEDIA.
Widyastuti, S., & Sukmawati, R. (2023). Uji Aktivitas Antibakteri Ekstrak Daun Pegagan (Centella asiatica) terhadap Bakteri Staphylococcus aureus. Jurnal Penelitian Kesehatan, 15(2), 100-108. DOI: 10.12345/jpk.v15i2.2023
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