Relationship Between Transaminase Enzyme Levels And Gamma GT In Diabetes Mellitus Patients With Diabetic Foot Ulcers
Hubungan Kadar Enzim Transaminase Dengan Gamma GT Pada Pasien Diabetes Mellitus Dengan Ulkus Kaki Diabetik
-
(1) * Hilda Emilia
Universitas Muhammadiyah Sidoarjo
Indonesia
(2) Andika Aliviameita Prodi Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Sidoarjo
Indonesia
(*) Corresponding Author
Abstract
Diabetes Mellitus is a chronic disease when the body cannot use insulin or cannot produce insulin enough, and glucose level in the blood increases. Diabetic ulcers are open sores on the skin surface caused by complications of macroangiophaty which can lead to neurophaty and vascular insufficiency. This study aims to determine the relationship between transaminase enzyme levels and Gamma GT in diabetes mellitus patients with diabetic foot ulcers. The sample used in this study was 30 patients with diabetes mellitus with diabetic foot ulcers. Research samples were obtained at Rumah Luka Sidoarjo and examined in the Hematology Laboratory of the Faculty of Health Sciences Muhammadiyah University in March 2021. SGOT and SGPT examination used the UV Enzymatic method, while the Gamma GT examination used the Enzymatic colorimetric method. In the Correlation-Regression test, it was found that there was no significant relationship (p=0,481) between SGOT Gamma GT, but there was a significant relationship (p=0,037) between SGPT and Gamma GT. Conclusion there is a moderate correlation (r=0,413) between transaminase anzymes and gamma GT in diabetes mellitus patients with diabetic foot ulcers.
References
Arisma, N. J. B., Yunus, M., & Fanani, E. (2017). Gambaran Pengetahuan Masyarakat Tentang Resiko Penyakit Diabetes Mellitus Di Kecamatan Pakisaji Kabupaten Malang. The Indonesia Journal of Public Health, 2(2), 1-9. doi: doi.org/10.17977/um044v2i2p67-75 DOI: https://doi.org/10.17977/um044v2i2p67-75
Ayu, A. S. (2017). Hubungan Perawatan Kaki Dengan Kejadian Luka Kaki Pada Penderita Diabetes Mellitus Di RSUD Dr. H. Abdul Moeloek Propinsi Lampung Tahun 2015. Jurnal Kesehatan Holistik, 11(2), 95-100. doi: doi.org/10.33024/hjk.v11i2.242
Azrimaidaliza. (2011). Asupan Zat Gizi Dan Penyakit Diabetes Mellitus, Jurnal Kesehatan Masyrakat, 1(6), 36-41. Retrieved from: http://jurnal.fkm.unand.ac.id/index.php/jkma/article/view/86 DOI: https://doi.org/10.24893/jkma.v6i1.86
Burhan, R. S., Muriman, Y. L., & Aziz, A. W. (2020). Hubungan Antara Tingkat Pengetahuan Dengan Gaya Hidup Pada Penderita Diabetes Mellitus. Jurnal Penelitian Perawat Profesional, 2(1), 105-114. Retrieved from: jurnal.globalhealthsciencegroup.com/index.php/JPPP DOI: https://doi.org/10.37287/jppp.v2i1.52
Choi, H. S., Kim, T. B., Shin, J., & Kim, N. K. (2020). Combined Effect of Serum Alanine Aminotransferase and Gamma-glutamyltransferase on Incidence of Diabetes Mellitus. Medicine, 99(11), 1-5. doi: 10.1097/MD.0000000000018963 DOI: https://doi.org/10.1097/MD.0000000000018963
Djamaluddin, D. (2016). Hubungan Perawatan Kaki Dengan Kejadian Luka Kaki Pada Penderita Diabetes Melitus Di RSUD Dr.H.Moeloek Propinsi Lampung Tahun 2015. Jurnal Kesehatan Holistik. 10(1), 15-19. Retrieved from: http://ejurnalmalahayati.ac.id/index.php/holistik/article/view/209
Fajkic, A., Lepara, O., Pepic, E., Dervisevic, A., Music, M., Buturovic, A. B., & Tuna, E. (2015). Metabolic Syndrome and Serum Liver Enzymes Level at Patients with Type 2 Diabetes Mellitus. Med Arch, 69(4), 251-255. doi: doi.org/10.5455%2Fmedarh.2015.69.251-255 DOI: https://doi.org/10.5455/medarh.2015.69.251-255
Hasanuddin, A., Thahir, S., & Hardianti D. (2019). Gambaran Kadar Serum Glutamate Oxalocetic Transminase (SGOT) Dan Glutamate Pyruvat Transminase (SGPT) Pada Pasien Diabetes Melitus Di RSUD Syekh Yusuf Kabupaten Gowa. Jurnal Media Laboran, 9(2), 23-28. Retieved from: https://uit.e-journal.id/MedLAb/article/view/577/424
Imelda, S. (2019). Faktor-Faktor Yang Mempengaruhi Terjadinya Diabetes Mellitus Di Puskesmas Harapan Jaya Tahun 2018. Scientia Journal, 8(1), 28-39. doi: doi.org/10.35141/scj.v8i1.406 Retrieved from http://diglib.unhas.ac.id/uploaded_files?temporary/DigitaCollection?NzQ0NDVjZDQ5ODQ3MTU5YTQ1MWMxZDhkNjM0YzI0OGViMzA5ZTYzZA==.pdf DOI: https://doi.org/10.35141/scj.v8i1.406
International Diabetes Federation (IDF). (2015). IDF Diabetes Atlas Seventh Edition. Retrieved from: https://diabetesatlas.org/upload/resources/previous/files/7/IDF%20Diabets%20Atlas%207th.pdf
Kemenkes, R. I. (2019). INFODATIN Pusat Data dan Informasi Kemeterian Kesehatan RI Situasi dan Analisa Diabetes. Retrieved from https://www.kemkes.go.id/download.php?file=download/pusdatin/infodati n/infodatin-diabetes.pdf
Lee, D. H., Gross, M. D., Steffes, M., Blomhoff, R., Jacobs, D. R., Christiani, D. C., Kim, J. H., & Ha, M. H. (2003). Gamma glutamyltransferase and diabetes-a 4 year follow-up study. Diabetologia, 46,359-364. doi: 10.1007/s00125-003-1046-5 DOI: https://doi.org/10.1007/s00125-003-1036-5
Musyafirah, D. (2017). Faktor Yang Berhubungan Dengan Kejadian Komplikasi DM Pada Penderita DM Di RS Ibnu Sina. Skripsi.
Universitas Hasanuddin Makassar. Retrieved from jurnal.globalhealthsciencegroup.com/index.php/JPPP
Reza, A., & Rachmawati, B. (2017). Perbedaan Kadar SGOT dan SGPT Antara Subyek Dengan Dan Tanpa Diabetes Mellitus, Jurnal Kedokteran Diponegoro. (6)2, 158-166. Retrieved from https://ejournal3.undip.ac.id/index.php/medico/article/view/18530
Schneider, C. L. A., Lazo, M., Ndumele, E. C., Pankow, S. J., Coresh, J., Clark, M. J., & Selvin, E. (2013). Liver enzymes, race, gender and diabetes risk: the Atherosclerosis Risk in Communities (ARIC) Study. Diabed Med, 30(8), 926-933. doi:10.1111/dme.12187 DOI: https://doi.org/10.1111/dme.12187
Susianti, R. A. (2018). Pengaruh Pemberian Epidermal Growth Factor pada Ulkus Diabetikum. Jurnal Kesehatan Dan Agromedicine, 5(2), 617-621. Retrieved from: https://juke.kedokteran.unila.ac.id/index.php/agro/article/view/2122
Trisnawati, S. K., & Setyorogo, S. (2013). Faktor Risiko Kejadian Diabetes Melitus Tipe II Di Puskesmas Kecamatan Cengkareng Jakarta Barat Tahun 2012. Jurnal Ilmiah Kesehatan, 5 (1), 6-11. Retrieved from http://fmipa.umri.ac.id/wp-content/uploads/2016/06/YUNI-INDRI-FAKTOR-RESIKO-DM.pdf
Wannamethe, G. S., Lennon, L., Whincup, H. P., & Shaper, G. A. (2005). Hepatic Enzymes, the Metabolic Syndrome, and the Risk of Type 2 Diabetes in Older Men. Diabetes Care, 28(12), 2913-2918. doi: doi.org/10.2337/diacare.28.12.2913 DOI: https://doi.org/10.2337/diacare.28.12.2913
Wulandari, N. A., Waluyo, A., & Irawati, D. (2019). Pengalaman Pasien Diabetes Mellitus Tipe 2 Dalam Melakukan Tindakan Pencegahan Terjadinya Luka Pada Kaki. Jurnal Keperawatan Silampari, 2(2), 176-188. doi: doi.org./10.31539/jks.v212.531 DOI: https://doi.org/10.31539/jks.v2i2.531
