Efficacy of Aloe vera Gel on the Excision Wound Healing in Sprague dawley Rats Efikasi Gel Lidah Buaya (Aloe vera) terhadap Kesembuhan Luka Eksisi pada Tikus Sprague dawley
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Published:
Aug 8, 2021
Keywords:
Aloe vera, gel, inflammation, macroscopy, wound healing
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Abstract
Wound is a pathological processes in all living things. Wound includes the overlapping mechanisms. The failure in wound healing causes infection. This study aimed to analyze the efficacy of Aloe vera gel in excisionwound on the rat’s back. This study used 18 male, Sprague Dawley rats, and they were induced excision wound on the back. The rats were separated into 3 groups, K1 = control, K2 = treated with betadin gel, K3 = treated with Aloe vera gel. The therapy was given twice a day for 7 days. The wound measurement was observed in day 3 and 7. The data were analyzed using SPSS. The result showed that Aloe vera gel potentially promote wound healing through the decrease microscopical condition of wound, re-epithelialization, and deposition of collagen better than in group K1 and K2 (p≤0.05). In conclusion, Aloe vera gel promote excision wound healing in Sprague Dawley rats.
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How to Cite
Palgunadi, B. U., Rahayu, A., & Prakoso, Y. A. (2021). Efficacy of Aloe vera Gel on the Excision Wound Healing in Sprague dawley Rats. Medicra (Journal of Medical Laboratory Science/Technology), 4(1), 46-49. https://doi.org/10.21070/medicra.v4i1.1432
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References
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Ceyssens, F., Deprez, M., Turner, N., Kil, D., van Kuyck, K., Welkenhuysen, M., Nuttin, B., Badylak, S., & Puers, R. (2017). Extracellular matrix proteins as temporary coating for thin-film neural implants. Journal of neural engineering, 14(1), 014001. https://doi.org/10.1088/1741-2552/14/1/014001.
Chang, A. C., Dearman, B., & Greenwood, J. E. (2011). A comparison of wound area measurement techniques: visitrak versus photography. Eplasty, 11, e18.
DePhillipo, N. N., Aman, Z. S., Kennedy, M. I., Begley, J. P., Moatshe, G., & LaPrade, R. F. (2018). Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries: A Systematic Review. Orthopaedic journal of sports medicine, 6(10), 2325967118804544. https://doi.org/10.1177/2325967118804544.
Feldman, A. T., & Wolfe, D. (2014). Tissue processing and hematoxylin and eosin staining. Methods in molecular biology (Clifton, N.J.), 1180, 31–43. https://doi.org/10.1007/978-1-4939-1050-2_3.
Gonzalez, A. C., Costa, T. F., Andrade, Z. A., & Medrado, A. R. (2016). Wound healing - A literature review. Anais brasileiros de dermatologia, 91(5), 614–620. https://doi.org/10.1590/abd1806-4841.20164741.
Kumar, V., Abbas, A. K., & Aster, J. C. 2013. Robbins BasicPathology.9th Ed. Elsevier. Philadelphia. Pp. 29-72.
Lugo, L. M., Lei, P., & Andreadis, S. T. (2011). Vascularization of the dermal support enhances wound re-epithelialization by in situ delivery of epidermal keratinocytes. Tissue engineering. Part A, 17(5-6), 665–675. https://doi.org/10.1089/ten.TEA.2010.0125.
Milne, C. T., Paine, T., Sullivan, V., & Sawyer, A. (2012). Content validation of terms and definitions in a wound glossary. The journal of the American College of Clinical Wound Specialists, 3(4), 71–76.https://doi.org/10.1016/j.jcws.2012.07.001.
Prakoso, Y. A., & Kurniasih (2018). The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing. Journal of tropical medicine, 2018, 6218303.https://doi.org/10.1155/2018/6218303.
Radha, M. H., & Laxmipriya, N. P. (2014). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of traditional and complementary medicine, 5(1), 21–26. https://doi.org/10.1016/j.jtcme.2014.10.006.
Rahmani, A. H., Aldebasi, Y. H., Srikar, S., Khan, A. A., & Aly, S. M. (2015). Aloe vera: Potential candidate in health management via modulation of biological activities. Pharmacognosy reviews, 9(18), 120–126. https://doi.org/10.4103/0973-7847.162118.
Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: a short review. Indian journal of dermatology, 53(4), 163–166. https://doi.org/10.4103/0019-5154.44785.
Wen, C. C., Chen, H. M., & Yang, N. S. (2012). Developing Phytocompounds from Medicinal Plants as Immunomodulators. Advances in botanical research, 62, 197–272. https://doi.org/10.1016/B978-0-12-394591-4.00004-0.
Wołuń-Cholewa, M., Szymanowski, K., Andrusiewicz, M., Szczerba, A., & Warchoł, J. B. (2010). Trichrome Mallory's stain may indicate differential rates of RNA synthesis in eutopic and ectopic endometrium. Folia Histochem Cytobiol, 48(1), 148-52. https://doi.org/10.2478/v10042-008-0106-4
Zhang, S., Liu, Y., Zhang, X., Zhu, D., Qi, X., Cao, X., Fang, Y., Che, Y., Han, Z. C., He, Z. X., Han, Z., & Li, Z. (2018). Prostaglandin E2 hydrogel improves cutaneous wound healing via M2 macrophages polarization. Theranostics, 8(19), 5348–5361. https://doi.org/10.7150/thno.27385