Influence of Hydrocortisone on Blood Profile, Total Protein, And Glucose in Female Rabbits
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(1) * Wasfi Dhahir Abid Ali
Department of Basic Science, College of Nursing, University of Basrah, Iraq
Iraq
(*) Corresponding Author
Abstract
The purpose of this study is to examine how hydrocortisone affects a few blood parameters in female rabbits. Ten local rabbits were split into two equal and random groups. As a control, the first group was employed. The second group received daily intramuscular injections of hydrocortisone at a dose of 0.1 mg/kg B.W. Blood serum was collected every day from the first day and evaluated for total cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), TG (triglycerides), and total protein after five weeks. The findings demonstrated that hydrocortisone reduced total protein and cholesterol.
References
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2- Lightman SL, Birnie MT, Conway-Campbell BL (June 2020). "Dynamics of ACTH and Cortisol Secretion and Implications for Disease". Endocrine Reviews. 41 (3). doi:10.1210/endrev/bnaa002. PMC 7240781. PMID 32060528.
3- Hoehn K, Marieb EN (2010). Human Anatomy & Physiology. San Francisco: Benjamin Cummings. ISBN 978-0-321-60261-9.
4- Sluiter JK, Frings-Dresen MH, Meijman TF, van der Beek AJ (May 2000). "Reactivity and recovery from different types of work measured by catecholamines and cortisol: a systematic literature overview". Occup Environ Med. 57 (5): 298–315. doi:10.1136/oem.57.5.298. PMC 1739955. PMID 10769296.
5- Laycock JF (2013). Integrated endocrinology. Meeran, Karim. Chichester, West Sussex, UK: Wiley-Blackwell. ISBN 978-1-118-45064-2. OCLC 794973804.
6- Djurhuus CB, Gravholt CH, Nielsen S, Mengel A, Christiansen JS, Schmitz OE, et al. (July 2002). "Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans". American Journal of Physiology. Endocrinology and Metabolism. 283 (1): E172–7. doi:10.1152/ajpendo.00544.2001. PMID 12067858. S2CID 2609285.
7- "Pandel (hydrocortisone probutate topical) dosing, indications, interactions, adverse effects, and more". Medscape. WebMD LLC. Retrieved 2023-02-26.
8- "Hydrocortisone Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD". WebMD LLC. Retrieved 2023-02-26.
9- "Hydrocortisone for skin: a steroid medicine for treating eczema, psoriasis and insect bites". Nhs.uk. 2019-01-17. Retrieved 2023-02-26.
10- Atger V, Leclerc T, Cambillau M, et al. Elevated high-density lipoprotein concentrations in heart transplant recipients are related to impaired plasma cholesteryl ester transfer and hepatic lipase activity. Atherosclerosis 1993;103(1):29- [http://dx.doi.org/10.1016/0021-9150(93)90037-U].
11- Hazra A, Pyszczynski NA, DuBois DC, Almon RR, Jusko WJ. Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats. Pharm Res 2008;25(4):769-780. [http://dx.doi.org/10.1007/s11095-007-9371-8]
12- Staels B, van Tol A, Chan L, Verhoeven G, Auwerx J. Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats. Arterioscler Thromb 1991;11(3):760-769. [http://dx.doi.org/10.1161/01.ATV.11.3.760
13- Scherbakova IA, Gerasimova EN, Perova NV, Titova VN, Koldaeva AP, Galakhova IE. [Effect of hydrocortisone on lipid composition of blood serum lipoproteins in the development of experimental atherosclerosis]. Vopr Med Khim 1975;21(6):589-595.
14- Quinkler M, Ekman B, Marelli C, Uddin S, Zelissen P, Murray RD; EU-AIR Investigators. Prednisolone is associated with a worse lipid profile than hydrocortisone in patients with adrenal insufficiency. Endocr Connect. 2017 Jan;6(1):1-8. doi: 10.1530/EC-16-0081. Epub 2016 Nov 18. PMID: 27864317; PMCID: PMC5148794.
15- Laycock JF (2013). Integrated endocrinology. Meeran, Karim. Chichester, West Sussex,
UK: Wiley-Blackwell. ISBN 978-1-118-45064-2. OCLC 794973804.
16- Loisa P, Parviainen I, Tenhunen J, Hovilehto S, Ruokonen E. Effect of mode of hydrocortisone administration on glycemic control in patients with septic shock: a prospective randomized trial. Crit Care. 2007;11(1): R21. doi: 10.1186/cc5696. PMID: 17306016; PMCID: PMC2151907.
17- Loisa P, Parviainen I, Tenhunen J, Hovilehto S, Ruokonen E. Effect of mode of hydrocortisone administration on glycemic control in patients with septic shock: a prospective randomized trial. Crit Care. 2007;11(1): R21. doi: 10.1186/cc5696. PMID: 17306016; PMCID: PMC2151907.
18- Jaymin Patel, Byron J Schneider, Clark C Smith, Spine Intervention Society’s Patient Safety Committee, Fact Finders for Patient Safety: Intra-Articular Corticosteroid Injections and Hyperglycemia, Pain Medicine, Volume 19, Issue 5, May 2018, Pages 1091–1092, doi: 10.1093/pm/pnx303.
Published
2025-05-30
How to Cite
Ali, W. D. A. (2025). Influence of Hydrocortisone on Blood Profile, Total Protein, And Glucose in Female Rabbits . Medicra (Journal of Medical Laboratory Science/Technology), 8(1), 5-7. https://doi.org/10.21070/medicra.v8i1.1783
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