Seroprevalence of Transfusion-Transmissible Infections among Blood Donors

Seroprevalensi Infeksi Menular Lewat Transfusi Darah pada Pendonor

Authors

  • Hartalina Mufidah Prodi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Universitas dr. Soebandi Jember, Indonesia
  • Dhika Juliana Sukmana Prodi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Ilmu Kesehatan, Poltekkes Kemenkes Yogyakarta, Indonesia

DOI:

https://doi.org/10.21070/medicra.v9i1.1773

Keywords:

HBsAg, HCV, HIV, Syphilis, TTIs

Abstract

Transfusion-Transmitted Infections (TTIs) is one of the crucial health problem of blood transfusions. In Jember Regency the number of HIV cases reported is relatively high. Meanwhile, data on the prevalence of cases of Hepatitis B, Hepatitis C and Syphilis is still lacking in Jember Regency. The aim of this study was to determine the prevalence, relationship and Prevalence Odds Ratio between variable age, gender, and donor status and the TTIs i.e HBsAg, HCV, HIV, syphilis. This study design is a cross-sectional. This study took secondary data of TTIs at the UDD PMI in Jember Regency from January to December 2019. The sampling technique was used total sampling, and 559 data were recorded. The data analysis used was univariate and chi-square, using SPSS version 20.0 software. The result of this study showed that the difference between age group and sex had p-value >0,05 with TTIs. Based on donor status, the difference between donor status had p-value <0,05 with TTIs. It can be conclude that the seroprevalence of TTIs at at the Blood Donor Unit Indonesian Red Cross in Jember Regency of HBsAg are 39.9%, HCV 65.1%, HIV 65.1%, and syphilis 59.2%. There is no relathioship between age and sex with TTIs and there is relathionship between donor status with TTIs. Prevalence Odds Ratio of HBsAg are 0.5 times, HCV are 1.8 times, HIV are 1.8 times, and syphilis 1,6 times more likely to be detected in repeat donors than in first-time donors.

References

Albshri, M., Manikandan, P., Allahyani, M., Aljuaid, A., Almehmadi, M. M., Alzabeedi, K., Babalgaith, M., Alghamdi, M., Alharbi, F., & Alhazmi, M. (2023). The Prevalence of Transfusion-Transmitted Diseases Among Blood Donors in the Central Blood Bank in Makkah, Saudi Arabia. Cureus, 15(11). https://doi.org/10.7759/cureus.48881

Alem, A. Z., Efendi, F., McKenna, L., Felipe-Dimog, E. B., Chilot, D., Tonapa, S. I., Susanti, I. A., & Zainuri, A. (2023). Prevalence and factors associated with anemia in women of reproductive age across low- and middle-income countries based on national data. Scientific Reports, 13(1), 1–13. https://doi.org/10.1038/s41598-023-46739-z

Ariani, N. L., Sudiwati, N. L. P. E., Panggayuh, A., & Widuri, S. (2024). Prevalensi Penyakit Infeksi Menular Lewat Transfusi Darah (IMLTD) Darah Donor di UDD PMI Kota Surabaya Tahun 2018-2022. Care : Jurnal Ilmiah Ilmu Kesehatan, 12(1), 153–165. https://doi.org/10.33366/jc.v12i1.5749

BADAN BPOM. (2018). PPOB CPOB di UTD dan Pusat Plasmaferesis. In Jakarta.

Bartonjo, G., Oundo, J., & Ng’ang’a, Z. (2019). Prevalence and associated risk factors of transfusion transmissibleinfections among blood donors at regional blood transfusion center nakuru and tenwek mission hospital, Kenya. Pan African Medical Journal, 34, 1–13. https://doi.org/10.11604/pamj.2019.34.31.17885

Chauhan, R., Kumar, R., & Thakur, S. (2022). A study to assess the knowledge, attitude, and practices about blood donation among medical students of a medical college in North India. Journal of Family Medicine and Primary Care, 6(2), 169–170. https://doi.org/10.4103/jfmpc.jfmpc

Chusna, S. Al, & Sari, W. (2023). Hasil Pemeriksaan Penyakit Infeksi Menular Lewat Transfusi Darah Dengan Metode Chlia Di Pmi Kota Banda Aceh. Prosiding Seminar Nasional Biologi, Teknologi Dan Kependidikan, 11(1), 13–25. https://jurnal.ar-raniry.ac.id/index.php/PBiotik/article/view/19065/8351

Dahie, H. A., Dakane, M. M., & Mudei, N. M. (2024). Seroprevalence of transfusion transmissible infections (TTIS) among blood donors in SOS hospital Heliwa, Somalia. Heliyon, 10(18), e37905. https://doi.org/10.1016/j.heliyon.2024.e37905

Deshmukh, S., Rathod, Y., Thakore, S., & Jadhav, S. (2024). Prevalence of Transfusion-Transmissible Infections Among Voluntary Blood Donors in a Tertiary Care Hospital. 16(9). https://doi.org/10.7759/cureus.70469

Dinas Kesehatan Provinsi Jawa Timur. (2024). Profil Kesehatan Provinsi Jawa Timur Tahun 2023. In Dinas Kesehatan Provinsi Jawa Timur, 11(1). http://scioteca.caf.com/bitstream/handle/123456789/1091/RED2017-Eng-8ene.pdf?sequence=12&isAllowed=y%0Ahttp://dx.doi.org/10.1016/j.regsciurbeco.2008.06.005%0Ahttps://www.researchgate.net/publication/305320484_SISTEM_PEMBETUNGAN_TERPUSAT_STRATEGI_MELESTARI

Gedefaw, G., Waltengus, F., Akililu, A., & Gelaye, K. (2019). Risk factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic at Felegehiwot referral hospital, Northwest Ethiopia, 2018: An institution based cross sectional study. BMC Research Notes, 12(1), 1–7. https://doi.org/10.1186/s13104-019-4561-0

Gudum, H. R., Sirucoh, C. A., Rukyno, N. A., Mogan, S., & Phing, T. S. (2024). Prevalence of Transfusion-transmissible Infections in Blood Donors: A Private Hospital Experience. Malaysian Journal of Medicine and Health Sciences, 20(2), 267–274. https://doi.org/10.47836/mjmhs.20.2.35

Jaffry, T. N., Khalid, S., Tariq, N., Fiaz, A., Zafar, S., & Yasir, S. (2019). Socio-Demographic Factors Influencing Voluntary Blood Donation in General Population of Islamabad, Pakistan. Community Medicine and Public Health Care, 6(3), 1–5. https://doi.org/10.24966/cmph-1978/100055

Kasraian, L., & Negarestani, N. (2015). Rates and reasons for blood donor deferral, Shiraz, Iran. A retrospective study. Sao Paulo Med J., 133(1), 36–42. https://doi.org/10.1590/1516-3180.2013.7110002

Kemenkes RI. (2022). Laporan Perkembangan HIV-AIDS dan Penyakit Infeksi Menular Seksual (PIMS) Triwulan 1 Januari-Maret 2022. In Kementrian Kesehatan Republik Indonesia.

Leitch, F., Pooran, L., Kurup, R., Lewis, P., & Boston, C. (2022). Trends in Transfusion-Transmissible Infections Among Blood Donors at the National Blood Transfusion Service, Guyana. Southeastern European Medical Journal, 6(1), 92–104. https://doi.org/10.26332/seemedj.v6i1.232

Lestari, T. R. P. (2024). Global Collaboration in Hepatitis Treatment: Indonesia’s Position and Role: Vol. XVI (Issue 14).

Mardhiyatillah, N., Ilhami, T., Akbar, S., Utariningsih, W., Program, M., Kedokteran, S., Kedokteran, F., Malikussaleh, U., Biokimia, D., Kedokteran, F., & Malikussaleh, U. (2024). Gambaran Hasil Skrining Infeksi Menular Lewat Transfusi Darah ( IMLTD ) Pendonor di Unit Transfusi Darah ( UTD ) PMI Kabupaten Aceh Utara Periode 2017-2021. 3(2), 15–24.

Mauka, W. I., Mahande, M. J., Msuya, S. E., & Philemon, R. N. (2015). Factors Associated with Repeat Blood Donation at the Northern Zone Blood Transfusion Centre in Tanzania. Journal of Blood Transfusion, 2015, 1–6. https://doi.org/10.1155/2015/717653

Mohamed, A. O., Hany, A. M. M., Fayed, H. M., & Ahmed, S. A. (2023). Frequency and risk factors for Hepatitis C virus seropositivity in blood transfusion-dependent thalassemic patients in Qena hospitals. SVU-International Journal of Medical Sciences, 6(2), 489–500. https://doi.org/10.21608/svuijm.2023.211460.1585

Mremi, A., Yahaya, J. J., Nyindo, M., & Mollel, E. (2021). Transfusion-Transmitted Infections and associated risk factors at the Northern Zone Blood Transfusion Center in Tanzania: A study of blood donors between 2017 and 2019. PLoS ONE, 16(3 March), 1–12. https://doi.org/10.1371/journal.pone.0249061

Permenkes RI. (2015). Peraturan Menteri Kesehatan No 91 Tahun 2015 Tentang Standar Pelayanan Transfusi Darah. In Menteri Kesehatan RI (Vol. 151). Menteri Kesehatan RI.

Rawat, A., Diwaker, P., Gogoi, P., & Singh, B. (2017). Seroprevalence & changing trends of transfusion-transmitted infections amongst blood donors in a Regional Blood Transfusion Centre in north India. Indian J Med Res, November 2(146), 642–645. https://doi.org/10.4103/ijmr.IJMR

Saputro, A. A., & Catur Retno Lestari. (2023). Gambaran Hasil Skrining Infeksi Menular Lewat Transfusi Darah (IMLTD) Pendonor di Unit Donor Darah (UDD) PMI Kabupaten Kudus Tahun 2021-2022 Info Articles. Indonesian Journal of Biomedical Science and Health, 3(1), 39–45. http://e-journal.ivet.ac.id/index.php/IJBSH

Shaikh, A. A., Alqasem, H. M., Alshubruqi, Y. A., Alasmari, S. Z., & Makkawi, M. H. (2024). Association of ABO, Rh-D and Kell blood groups with transfusion transmitted infections among blood donors from the Asir Region, Saudi Arabia A retrospective observational study. Saudi Medical Journal, 45(4), 414–423. https://doi.org/10.15537/smj.2024.45.4.20240007

Singogo, E., Chagomerana, M., Van Ryn, C., M’bwana, R., Likaka, A., M’baya, B., Puerto-Meredith, S., Chipeta, E., Mwapasa, V., Muula, A., Reilly, C., & Hosseinipour, M. C. (2023). Prevalence and incidence of transfusion- transmissible infections among blood donors in Malawi: A population-level study. Transfusion Medicine, 33(6), 483–496. https://doi.org/10.1111/tme.13006

Siraj, N., Achila, O. O., Issac, J., Menghisteab, E., Hailemariam, M., Hagos, S., Gebremeskel, Y., & Tesfamichael, D. (2018). Seroprevalence of transfusion-transmissible infections among blood donors at National Blood Transfusion Service, Eritrea: A seven-year retrospective study. BMC Infectious Diseases, 18(1), 1–9. https://doi.org/10.1186/s12879-018-3174-x

Soumena, R. Z., Noya, F. C., Rahawarin, H., Bandjar, F. K., Lima, F. V. I. de, Asmin, E., Agustin, R. D., Sulfiana, Yunita, M., Mus, R., Latuheru, G., & Warella, J. C. (2022). Hubungan Kadar Hemoglobin dengan Usia pada Wanita di Gugus Pulau Kei Tual Provinsi Maluku. Molluca Medica, 17(November 2024), 1–5. https://doi.org/10.30598/molmed.2024.v17.ik.1

Su, F., Cao, L., Ren, X., Hu, J., Tavengana, G., Wu, H., Zhou, Y., Fu, Y., Jiang, M., & Wen, Y. (2023). Age and sex trend differences in hemoglobin levels in China: a cross-sectional study. BMC Endocrine Disorders, 23(1), 8. https://doi.org/10.1186/s12902-022-01218-w

Suastika, K., Dwipayana, P., Ratna Saraswati, I. M., Kuswardhani, T., Astika, N., Putrawan, I. B., Matsumoto, K., Kajiwara, N., & Taniguchi, H. (2011). Relationship between age and metabolic disorders in the population of Bali. Journal of Clinical Gerontology and Geriatrics, 2(2), 47–52. https://doi.org/10.1016/j.jcgg.2011.03.001

Swetha, Jayakumar, N., Prashath, N. P., Udayakumar, A., & Chandiran Joseph, A. (2024). Knowledge, Attitude, and Practice Regarding Blood Donation Among Undergraduate Medical Students-A Cross Sectional Study. International Journal of Academic Medicine and Pharmacy, 506–510. https://doi.org/10.47009/jamp.2024.6.2.110

Tang, Z., Gou, Y., Zhang, K., Zhao, Z., Wei, Y., Li, D., Chen, L., & Chuanmin Tao. (2020). Clinical Laboratory Analysis - 2020 - Tang - The evaluation of low cut‐off index values of Elecsys HIV combi PT assay in.pdf. J Clin Lab Anal., 1–6. https://doi.org/DOI: 10.1002/jcla.23503

Teklemariam, Z., Mitiku, H., & Weldegebreal, F. (2018). Seroprevalence and trends of transfusion transmitted infections at Harar blood bank in Harari regional state, Eastern Ethiopia: Eight years retrospective study. BMC Hematology, 18(1), 1–8. https://doi.org/10.1186/s12878-018-0115-2

Uliani, Nur Afni, & Herlina Yusuf. (2020). Faktor- Faktor yang Berhubungan dengan Penyakit HIV pada Pendonor Darah di UTD PMI Provinsi Sulawesi Tengah. Jurnal Kolaboratif Sains, 3(5), 256–261. https://doi.org/10.56338/jks.v3i5.1724

Wadood, M., & Usman, M. (2019). Comparative Analysis of Electrochemiluminescence Assay and Chemiluminescent Microparticle Immunoassay for the Screening of Hepatitis C. Indian Journal of Hematology and Blood Transfusion, 35(1), 131–136. https://doi.org/10.1007/s12288-018-0968-3

Wu, Y., Ling, X., Yu, G., Zhu, H., Hu, W., Pu, C., & Zhu, F. (2019). The efficacy of HBsAg detection using electro-chemiluminescence immunoassay for blood donor screening in China. Annals of Blood, 4, 30–30. https://doi.org/10.21037/aob.2019.12.02

Yulianti, S., Ilhami Surya Akbar, T., & Zara, N. (2023). Hubungan Status Gizi dan Asupan Protein dengan Kadar Hemoglobin Calon Pendonor di UDD PMI Aceh Utara. Jurnal Ilmmiah Manusia Dan Kesehatan, 6(3), 429–438.

Zhou, J., Liang, Y., Zhang, J., & Cui, L. (2017). The analyzation and clinical evaluation of ECLIA and CMIA in the detection of Treponema pallidum. Medicine (United States), 96(24), 1–4. https://doi.org/10.1097/MD.0000000000007139

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Published

2026-07-14

How to Cite

Mufidah, H., & Sukmana, D. J. (2026). Seroprevalence of Transfusion-Transmissible Infections among Blood Donors: Seroprevalensi Infeksi Menular Lewat Transfusi Darah pada Pendonor . Medicra (Journal of Medical Laboratory Science Technology), 9(1), 1–8. https://doi.org/10.21070/medicra.v9i1.1773

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