Diagnostic Test of FNAB Towards Histopathology in Lipoma Soft Tissue Tumor Patients


Uji Diagnosis FNAB Terhadap Histopatologi Pada Pasien Tumor Jaringan Lunak Lipoma


  • (1)  Jihan Azzahra Arsyi            Poltekkes Kemenkes Surabaya  
            Indonesia

  • (2) * Anik Handayati            Politeknik Kesehatan Kemenkes Surabaya  
            Indonesia

  • (3)  Sri Sulami Endah Astuti            Poltekkes Kemenkes Surabaya  
            Indonesia

    (*) Corresponding Author

Abstract

Lipomas are the most common soft tissue tumor neoplasms. Their range from benign lipomas to high grade liposarcomas. Liposarcoma happens when the neoplasm of a lipoma is malignant. There are various diagnostic methods that can be used to evaluate lipomas, one of which is Fine Needle Aspiration Biopsy (FNAB). FNAB is the initial diagnosis to determine the diagnosis of lipoma soft tissue tumors. Histopathology is the definitive diagnosis or the gold standard for diagnosing lipoma soft tissue tumors. This research aims to determine the value of the Fine Needle Aspiration Biopsy diagnostic test against histopathological tests as the gold standard in lipoma soft tissue tumor patients. This research is a retrospective with a descriptive observational design. This research involved taking medical records of patients with lipoma soft tissue tumors who were examined by FNAB at RSPAL dr. Ramelan, Surabaya for the period August 2019 - December 2021. The results of the FNAB examination were then matched against the histopathological examination data as the gold standard. Data processing using 2x2 cross tabulation to calculate the diagnostic test which includes sensitivity, specificity, positive predictive value, negative predictive value, and accuracy against the gold standard. The results of the Fine Needle Aspiration Biopsy diagnostic test for histopathology in soft tissue lipoma tumors obtained sensitivity of 100.00%, specificity 95.83%, positive predictive value (NRP) 87.5%, negative predictive value (NRN) 100.00%, and 96.77% accuracy. Fine Needle Aspiration Biopsy (FNAB) has good diagnostic value for diagnosing lipoma soft tissue tumors.

References

Allen, D. C., & Cameron, R. I. (2017). Histopathology Specimens. Cham: Springer Nature

Harahap, W. A. (2015). Pembedahan Pada Tumor Ganas Payudara. Majalah Kedokteran Andalas, 38(1), 54-62. Retrieved from http://jurnalmka.fk.unand.ac.id/index.php/art/article/view/267

Ismael & Sastroasmoro. (2014). Dasar-Dasar Metodologi Penelitian Klinis (Edisi-5). Jakarta: Sagung Seto.

Johnson, Christopher N., Alice S. Ha, Eleanor Chen, and Darin Davidson. (2018). Lipomatous Soft-Tissue Tumors. Journal of the American Academy of Orthopaedic Surgeons, 26(22), 779–88. doi: 10.5435/JAAOS-D-17-00045

Kolb, L., S, S. N., Yarrarapu, Ameer, M. A., & Rosario-Collazo, J. A. (2021, December 29). Lipoma. National Center for Biotechnology Information. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK507906

Mahyudin, Ferdiansyah. (2017). Diagnosis Dan Terapi Tumor Muskuloskeletal. Journal of Chemical Information and Modeling, 53(9): 1689–99. Retrieved from https://pubstore.acs.org/jcisd8-53-9.html

Norahmawati, E. (2019). Biopsi Aspirasi Jarum Halus Tumor Jaringan Lunak Jurnal Kedokteran Brawijaya, 15(2), 77-82 Retrieved from https://jkb.ub.ac.id/index.php/jkb/article/view/181/178

Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI). (2015). Buku Pedoman Pelayanan Patologi Anatomi Indonesia. pp.1–10.

Regita, Amanda Novia. (2018). Nilai Diagnostik Fine Needle Aspiration Biopsy (FNAB) Untuk Membedakan Tumor Jinak dan Tumor Ganas Tulang Dengan Baku Emas Histopatologi. Skripsi. Fakultas Kedokteran. Universitas Brawijaya. Malang

Ritonga, E. (2020). Profil Penderita Soft Tissue Tumor Di Laboratorium Patologi Rumah Sakit Advent Medan Tahun 2016-2017. Jurnal Universitas Sumatera Utara, 18(2), 35–38. Retrieved from https://repositori.usu.ac.id/handle/123456789/30387

Technische Universtität München, L.-M.-U. M. (2018). Perbandingan Tingkat Ketepatan Diagnosis Kanker Payudara Antara Biopsi Jarum Halus dengan Histopatologi di RSUD DR. H. Abdul Moeloek Bandar Lampung Tahun 2015. Jurnal Ilmu Kedokteran dan Kesehatan, 2(2), 40-47. Retrieved from https://ejurnalmalahayati.ac.id/index.php/kesehatan/article/view/698

Witjaksono, S. W. (2015). Akurasi Diagnosis FNAB (Fine Needle Aspiration Biopsy) pada Tumor Muskuloskeletal di Instalasi Patologi Anatomi Rumah Sakit Umum dr. Saiful Anwar Malang Periode Tahun 2011-2013. Skripsi. Universitas Brawijaya. Malang.

Picture in here are illustration from public domain image (License) or provided by the author, as part of their works
Published
2023-12-31
 
How to Cite
Jihan Azzahra Arsyi, Handayati, A., & Sri Sulami Endah Astuti. (2023). Diagnostic Test of FNAB Towards Histopathology in Lipoma Soft Tissue Tumor Patients. Medicra (Journal of Medical Laboratory Science/Technology), 6(2), 38-43. https://doi.org/10.21070/medicra.v6i2.1653
Section
Articles