The Relationship between Microalbumin Levels and HbA1c in People at Risk for Type 2 Diabetes Mellitus Hubungan Kadar Mikroalbumin dan HbA1c pada Orang dengan Resiko Diabetes Mellitus Tipe 2

Main Article Content

Leo Yosdimyati Romli

Abstract

Increased blood glucose levels in diabetes mellitus are a problem due to poor insulin synthesis, and insulin resistance conditions cause microalbumin. The purpose of this study was to determine the relationship between microalbumin levels and HbA1c in people at risk for type 2 diabetes mellitus. This type of research is a quantitative study using a cross-sectional study design. Respondents in this study were all women at risk of type 2 diabetes mellitus in the village of Ngrandulor. The research sample was taken using the purposive sampling technique, which was taken according to the criteria set by the researcher so that 28 respondents were selected. Data collection on microalbumin levels was carried out by immunoturbidimetric examination, and HbA1c was carried out by immunoassay examination. Bivariate analysis of the research data was carried out using the Spearman rank statistical test. The results showed a relationship between microalbumin levels and HbA1c in people at risk for type 2 diabetes mellitus, the p-value = 0.010. The results showed that half of the respondents had their albumin checked under microalbumin conditions, namely 14 respondents (50%) and on HbA1c examination, which showed that they were in diabetes status or conditions, namely 14 respondents (50%). This study concludes that there is a relationship between microalbumin levels and HbA1c in people at risk for type 2 diabetes mellitus, with a significance value (p) of 0.010.

Article Details

How to Cite
Romli , L. Y. (2021). The Relationship between Microalbumin Levels and HbA1c in People at Risk for Type 2 Diabetes Mellitus. Medicra (Journal of Medical Laboratory Science/Technology), 4(2), 88-92. https://doi.org/10.21070/medicra.v4i2.1612
Section
Articles

References

ADA. (2017). 4. Lifestyle Management. Diabetes Care, 40(Supplement 1), S33–S43. doi:10.2337/DC17-S007
ADA. (2019). 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2019. In Diabetes Care (Vol. 42, Issue Supplement 1, pp. S13–S28). American Diabetes Association. doi: 10.2337/DC19-S002
Al Mansour, M. A. (2020). The prevalence and risk factors of type 2 diabetes mellitus (DMT2) in a semi-urban Saudi population. International Journal of Environmental Research and Public Health, 17(1), 1–8. doi: 10.3390/ijerph17010007
Berbudi, A., Rahmadika, N., Tjahjadi, A. I., & Ruslami, R. (2020). Type 2 Diabetes and its Impact on the Immune System. Current Diabetes Reviews, 16(5), 442. doi: 10.2174/1573399815666191024085838
Berelaku, J. A. (2019). Hubungan Kadar Mikroalbumin Urine Terhadap Kreatinin Serum Pada Penderita Diabetes Mellitus Menahun Di Puskesmas Sikumana, Manutapen, Oepoi, Pasir Panjang Dan Naioni Tahun 2019. Karya Tulis Ilmiah. Poltekkes Kupang. Nusa Tenggara Timur
Chaudhury, A., Duvoor, C., Reddy., Dendi, V. S., Kraleti, S., Chada, A., Ravilla, R., Marco, A., Shekhawat, N. S., Montales, M. T., Kuriakose, K., Sasapu, A., Beebe, A., Patil, N., Musham, C. K., Lohani, G. P., & Mirza, W. (2017). Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management. Frontiers in Endocrinology, 8, 6. doi: 10.3389/FENDO.2017.00006/BIBTEX
Czech, M. P. (2017). Insulin action and resistance in obesity and type 2 diabetes. Nature Medicine, 23(7), 804. doi: 10.1038/NM.4350
De Boer, I. H., Bangalore, S., Benetos, A., Davis, A. M., Michos, E. D., Muntner, P., Rossing, P., Zoungas, S., & Bakris, G. (2017). Diabetes and Hypertension: A Position Statement by the American Diabetes Association. Diabetes Care, 40(9), 1273–1284. doi: 10.2337/DCI17-0026
Dhatariya, K., Corsino, L., & Umpierrez, G. E. (2020). Management of Diabetes and Hyperglycemia in Hospitalized Patients. Endotext. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK279093/
Fandinata, S. S. (2019). Perubahan Kadar Protein dalam Urin terhadap Penggunaan Obat Antihipertensi (Valsartan) pada Pasien Nefropati. Journal of Pharmacy and Science, 4(1), 1–6. doi: 10.53342/pharmasci.v4i1.121
IDF. (2019). IDF Diabetes Atlas Ninth Edition 2019. In International Diabetes Federation. International Diabetes Federation. www.diabetesatlas.org
Indriani, V., Siswandari, W., Samudro, P., & Inayati, N. S. (2020). Correlation between albumin creatinine ratio and hypertension in type 2 diabetes. JHeS (Journal of Health Studies), 4(1), 1–6. doi: 10.31101/jhes.1351
MacIsaac, R. J., Jerums, G., & Ekinci, E. I. (2017). Effects of glycaemic management on diabetic kidney disease. World Journal of Diabetes, 8(5), 172. doi: 10.4239/WJD.V8.I5.172
Persson, F., & Rossing, P. (2018). Diagnosis of diabetic kidney disease: state of the art and future perspective. Kidney International Supplements, 8(1), 2. doi: 10.1016/J.KISU.2017.10.003
Wahiduddin, Pranoto, A., & Sudjarwo. (2019). Kendali Glikemik pada Pasien Diabetes Melitus Tipe 2 dengan dan tanpa Tuberkulosis Paru. Jurnal MKMI, 15(1), 99–109. doi: 10.30597/mkmi.v15i1.5292
Pugh, D., Gallacher, P. J., & Dhaun, N. (2019). Management of Hypertension in Chronic Kidney Disease. Drugs, 79(4), 365. doi: 10.1007/S40265-019-1064-1
Sarihati, I. G. A. D., Karimah, H. N., & Habibah, N. (2019). Gambaran Kadar HbA1c pada Pasien Diabetes Melitus Tipe 2 di RSUD Wangaya. Meditory : The Journal of Medical Laboratory, 6(2), 88–98. doi: 10.33992/m.v6i2.442
Tapia, C., & Bashir, K. (2021). Nephrotic Syndrome. StatPearls. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK470444/
Vaidya, S. R., & Aeddula, N. R. (2021). Chronic Renal Failure. The Scientific Basis of Urology, Second Edition, 257–264. doi: 10.29309/tpmj/2009.16.04.2736
Vallon, V., & Komers, R. (2011). Pathophysiology of the Diabetic Kidney. Comprehensive Physiology, 1(3), 1175. doi: 10.1002/CPHY.C100049
Wasik, A. A., & Lehtonen, S. (2018). Glucose transporters in diabetic kidney disease-friends or foes? Frontiers in Endocrinology, 9(APR), 155. doi: 10.3389/FENDO.2018.00155/BIBTEX